Title : Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1.

Pub. Date : 2009 Jun 30

PMID : 19332109






1 Functional Relationships(s)
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1 Converging evidence from pharmacological and molecular studies has led to the suggestion that inhibition of glycine transporter 1 (GlyT1) constitutes an effective means to boost N-methyl-d-aspartate receptor (NMDAR) activity by increasing the extra-cellular concentration of glycine in the vicinity of glutamatergic synapses. Glycine solute carrier family 6 (neurotransmitter transporter, glycine), member 9 Mus musculus