Pub. Date : 2008
PMID : 19326769
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DEET significantly induced CYP3A4, CYP2B6, CYP2A6 and CYP1A2 mRNA expression while chlorpyrifos induced CYP1A1, CYP1A2 and CYP3A4 mRNA, and to a lesser extent, CYP1B1 and CYP2B6 mRNA in primary human hepatocytes. | Chlorpyrifos | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | Chlorpyrifos and DEET also mediated the expression of CYP isoforms, particularly CYP3A4, CYP2B6 and CYP1A1, as shown by CYP3A4-specific protein expression, testosterone metabolism and CYP1Al-specific activity assays. | Chlorpyrifos | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |