Title : Induction of prostaglandin E2 pathway promotes gastric hamartoma development with suppression of bone morphogenetic protein signaling.

Pub. Date : 2009 Apr 1

PMID : 19318548






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1 Notably, treatment of K19-Nog/C2mE mice with a cyclooxygenase-2 inhibitor, celecoxib, significantly reduced tumor size with suppression of angiogenesis, suggesting that induction of the PGE(2) pathway together with inhibition of BMP signaling is required for gastric hamartoma development. Celecoxib noggin Mus musculus