Pub. Date : 2009 Jul
PMID : 19303460
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The associations between in vitro PCB metabolism, activity of oxidative hepatic microsomal cytochrome P450 (CYP) isoenzymes and concentrations of PCBs and hydroxylated metabolites were investigated. | Polychlorinated Biphenyls | Cytochrome P450 1A1 | Canis lupus familiaris |
| 2 | The associations between in vitro PCB metabolism, activity of oxidative hepatic microsomal cytochrome P450 (CYP) isoenzymes and concentrations of PCBs and hydroxylated metabolites were investigated. | Polychlorinated Biphenyls | Cytochrome P450 1A1 | Canis lupus familiaris |
| 3 | This depletion discrepancy suggests that there exist substrates in liver of the organohalogen-contaminated EXP dogs that can competitively bind and/or interfere with the active sites of CYP isoenzymes, leading to a lower metabolic efficiency for these PCBs. | Polychlorinated Biphenyls | Cytochrome P450 1A1 | Canis lupus familiaris |
| 4 | Based on documented hepatic microsomal CYP isoenzyme substrate specificities in canines, present associations suggest that primarily CYP2B/2C and CYP3A were inducible in sledge dogs and responsible for the in vitro metabolism of PCB-18 and -33. | Polychlorinated Biphenyls | Cytochrome P450 1A1 | Canis lupus familiaris |