Title : Pretreatment with R(+)-verapamil significantly reduces mortality and cytokine expression in murine model of septic shock.

Pub. Date : 2009 Apr

PMID : 19291858






2 Functional Relationships(s)
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1 The aim of this study was to assess the influence of P-gp inhibitor, R(+)-verapamil, on cytokine expression in serum and tissues as well as survival rate of mice with LPS-induced septic shock. Verapamil phosphoglycolate phosphatase Mus musculus
2 R(+)verapamil improves survival of mice receiving a lethal dose of LPS and significantly potentiates the protective effect of pentoxifylline and prednisolone against LPS-induced lethality, probably as a result of both P-gp inhibition and a synergistic interaction at the gene level. Verapamil phosphoglycolate phosphatase Mus musculus