Pub. Date : 2009
PMID : 19287496
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation. | Nicotine | forkhead box M1 | Homo sapiens |
| 2 | Screening putative carcinogens in human oral keratinocytes surprisingly showed that nicotine, which is not perceived to be a human carcinogen, directly induced FOXM1 mRNA, protein stabilisation and transcriptional activity at concentrations relevant to tobacco chewers. | Nicotine | forkhead box M1 | Homo sapiens |
| 3 | Importantly, nicotine also augmented FOXM1-induced transformation of human oral keratinocytes. | Nicotine | forkhead box M1 | Homo sapiens |