Pub. Date : 2009 May
PMID : 19286927
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells. | Ceramides | tumor necrosis factor | Homo sapiens |
| 2 | Because TNFalpha had been shown to activate ceramide accumulation, and separate studies had linked ceramide with activation of PP2A, we hypothesized the pathway of TNFalpha-inducing ceramide to activate PP2A comprised an endogenous regulatory pathway. | Ceramides | tumor necrosis factor | Homo sapiens |
| 3 | Because TNFalpha had been shown to activate ceramide accumulation, and separate studies had linked ceramide with activation of PP2A, we hypothesized the pathway of TNFalpha-inducing ceramide to activate PP2A comprised an endogenous regulatory pathway. | Ceramides | tumor necrosis factor | Homo sapiens |
| 4 | Because TNFalpha had been shown to activate ceramide accumulation, and separate studies had linked ceramide with activation of PP2A, we hypothesized the pathway of TNFalpha-inducing ceramide to activate PP2A comprised an endogenous regulatory pathway. | Ceramides | tumor necrosis factor | Homo sapiens |
| 5 | Because TNFalpha had been shown to activate ceramide accumulation, and separate studies had linked ceramide with activation of PP2A, we hypothesized the pathway of TNFalpha-inducing ceramide to activate PP2A comprised an endogenous regulatory pathway. | Ceramides | tumor necrosis factor | Homo sapiens |
| 6 | In summary, our data suggest that in respiratory epithelium, TNFalpha induces ceramide accumulation, resulting in subsequent activation of PP2A, which targets those kinases responsible for transcriptional activation of IL-8. | Ceramides | tumor necrosis factor | Homo sapiens |