Pub. Date : 2009 Apr 24
PMID : 19275878
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ABCA1 modulates the oligomerization and Golgi exit of caveolin-1 during HDL-mediated cholesterol efflux in aortic endothelial cells. | Cholesterol | ATP binding cassette subfamily A member 1 | Rattus norvegicus |
| 2 | Previously, the authors have shown that the molecular interaction between caveolin-1 and ATP-binding cassette transporter A1 (ABCA1) is associated with the high-density lipoprotein (HDL)-mediated cholesterol efflux pathway in aortic endothelial cells (ECs). | Cholesterol | ATP binding cassette subfamily A member 1 | Rattus norvegicus |
| 3 | Previously, the authors have shown that the molecular interaction between caveolin-1 and ATP-binding cassette transporter A1 (ABCA1) is associated with the high-density lipoprotein (HDL)-mediated cholesterol efflux pathway in aortic endothelial cells (ECs). | Cholesterol | ATP binding cassette subfamily A member 1 | Rattus norvegicus |
| 4 | This study analyzed the role ABCA1 plays in caveolin-1-mediated cholesterol efflux in aortic ECs. | Cholesterol | ATP binding cassette subfamily A member 1 | Rattus norvegicus |
| 5 | Knockdown of ABCA1 by siRNA in primary rat aortic ECs after cholesterol treatment did not affect caveolin-1 expression but led to the retention of caveolin-1 in the Golgi apparatus, impaired caveolin-1 oligomerization, and reduced cholesterol efflux. | Cholesterol | ATP binding cassette subfamily A member 1 | Rattus norvegicus |
| 6 | Knockdown of ABCA1 by siRNA in primary rat aortic ECs after cholesterol treatment did not affect caveolin-1 expression but led to the retention of caveolin-1 in the Golgi apparatus, impaired caveolin-1 oligomerization, and reduced cholesterol efflux. | Cholesterol | ATP binding cassette subfamily A member 1 | Rattus norvegicus |
| 7 | It is concluded that HDL up-regulates ABCA1 expression, which in turn modulates the oligomerization and Golgi exit of caveolin-1 to enhance cholesterol efflux in aortic ECs. | Cholesterol | ATP binding cassette subfamily A member 1 | Rattus norvegicus |