Title : Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.

Pub. Date : 2009 Mar 16

PMID : 19273625






2 Functional Relationships(s)
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1 Furthermore, PGE2 synergizes with IL-1beta and IL-23 to drive retinoic acid receptor-related orphan receptor (ROR)-gammat, IL-17, IL-17F, CCL20, and CCR6 expression, which is consistent with the reported Th17 phenotype. Dinoprostone interleukin 17A Homo sapiens
2 Furthermore, PGE2 is required for IL-17 production in the presence of antigen-presenting cells. Dinoprostone interleukin 17A Homo sapiens