Pub. Date : 2009 Apr 16
PMID : 19270727
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner. | Paclitaxel | RAN binding protein 1 | Homo sapiens |
| 2 | Several observations indicate that RanBP1 contributes to regulate the function of the mitotic apparatus: RanBP1 inactivation yields hyperstable MTs and induces apoptosis during mitosis, reminiscent of the effects of the MT-stabilizing drug taxol. | Paclitaxel | RAN binding protein 1 | Homo sapiens |
| 3 | Here we have investigated the influence of RanBP1 on spontaneous and taxol-induced apoptosis in transformed cells. | Paclitaxel | RAN binding protein 1 | Homo sapiens |
| 4 | Furthermore, RanBP1-interfered cells show an increased apoptotic response to taxol compared to their counterpart with normal or high RanBP1 levels, and this response is caspase-3 dependent. | Paclitaxel | RAN binding protein 1 | Homo sapiens |
| 5 | Furthermore, RanBP1-interfered cells show an increased apoptotic response to taxol compared to their counterpart with normal or high RanBP1 levels, and this response is caspase-3 dependent. | Paclitaxel | RAN binding protein 1 | Homo sapiens |