Title : Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity.

Pub. Date : 2009 Apr 1

PMID : 19268584






1 Functional Relationships(s)
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1 By virtue of the installation of alternative halogenated piperidinyl benzimidazolone privileged structures, in combination with a key (S)-methyl group, novel PLD inhibitors with low nM potency and unprecedented levels of PLD1 isoform selectivity (approximately 1700-fold) over PLD2 were developed. piperidinyl benzimidazolone phospholipase D1 Homo sapiens