Pub. Date : 2009 May 1
PMID : 19265195
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in beta4-galactosyltransferase-II-deficient mice. | Carbohydrates | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | Mus musculus |
| 2 | Immunohistochemistry showed that the amount of HNK-1 carbohydrate was markedly decreased in the brain of beta4GalT-II(-/-) mice, whereas the expression of polysialic acid was not affected. | Carbohydrates | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | Mus musculus |
| 3 | Furthermore, mice deficient in glucuronyltransferase (GlcAT-P), which is responsible for the biosynthesis of the HNK-1 carbohydrate, also showed impaired spatial learning/memory as described in our previous report, although their motor coordination/learning was normal as shown in this study. | Carbohydrates | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | Mus musculus |
| 4 | Furthermore, mice deficient in glucuronyltransferase (GlcAT-P), which is responsible for the biosynthesis of the HNK-1 carbohydrate, also showed impaired spatial learning/memory as described in our previous report, although their motor coordination/learning was normal as shown in this study. | Carbohydrates | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | Mus musculus |
| 5 | These results suggest that the Galbeta1-4GlcNAc structure in the HNK-1 carbohydrate is mainly synthesized by beta4GalT-II and that the glycans synthesized by beta4GalT-II have essential roles in higher brain functions, including some that are HNK-1-dependent and some that are not. | Carbohydrates | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | Mus musculus |
| 6 | These results suggest that the Galbeta1-4GlcNAc structure in the HNK-1 carbohydrate is mainly synthesized by beta4GalT-II and that the glycans synthesized by beta4GalT-II have essential roles in higher brain functions, including some that are HNK-1-dependent and some that are not. | Carbohydrates | beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) | Mus musculus |