Title : Efficiency of methemoglobin, hemin and ferric citrate in catalyzing protein tyrosine nitration, protein oxidation and lipid peroxidation in a bovine serum albumin-liposome system: influence of pH.

Pub. Date : 2009 May

PMID : 19264360






2 Functional Relationships(s)
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1 In this paper, a BSA (bovine serum albumin)-lecithin liposome system was used to study the nature of different forms of iron, including methemoglobin, hemin and ferric citrate, in catalyzing H(2)O(2)-nitrite system to oxidize protein and lipid as well as nitrate protein. Iron hemoglobin subunit gamma 2 Homo sapiens
2 Considering protein tyrosine nitration, protein oxidation and lipid oxidation as overall oxidative damage, these results indicated that methemoglobin is more toxic than hemin and ferric citrate, the degradation procedure of heme containing macromolecules, e.g. hemoglobin to hemin and finally to low molecular weight bounded iron, is step by step detoxification. Iron hemoglobin subunit gamma 2 Homo sapiens