Pub. Date : 2009 Apr 1
PMID : 19258390
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interestingly, DAG to which PKD1 is recruited in this pathway is formed downstream of phospholipase D1 (PLD1) and a lipase-inactive PLD1 or inhibition of PLD1 by pharmacological inhibitors blocked PKD1 activation under oxidative stress. | Diglycerides | phospholipase D1 | Homo sapiens |
| 2 | Interestingly, DAG to which PKD1 is recruited in this pathway is formed downstream of phospholipase D1 (PLD1) and a lipase-inactive PLD1 or inhibition of PLD1 by pharmacological inhibitors blocked PKD1 activation under oxidative stress. | Diglycerides | phospholipase D1 | Homo sapiens |
| 3 | Interestingly, DAG to which PKD1 is recruited in this pathway is formed downstream of phospholipase D1 (PLD1) and a lipase-inactive PLD1 or inhibition of PLD1 by pharmacological inhibitors blocked PKD1 activation under oxidative stress. | Diglycerides | phospholipase D1 | Homo sapiens |
| 4 | Interestingly, DAG to which PKD1 is recruited in this pathway is formed downstream of phospholipase D1 (PLD1) and a lipase-inactive PLD1 or inhibition of PLD1 by pharmacological inhibitors blocked PKD1 activation under oxidative stress. | Diglycerides | phospholipase D1 | Homo sapiens |
| 5 | To date it has been viewed that monosaturated and saturated DAG formed via PLD1 have no signaling function. | Diglycerides | phospholipase D1 | Homo sapiens |
| 6 | However, our data describe a role for PLD1-induced DAG as a competent second messenger at the mitochondria that relays ROS to PKD1-mediated mitochondria-to-nucleus signaling. | Diglycerides | phospholipase D1 | Homo sapiens |