Pub. Date : 2009 Apr
PMID : 19256530
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, serum metabolomes of control and APAP-treated wild-type and Cyp2e1-null mice were examined by liquid chromatography-mass spectrometry (LC-MS) and multivariate data analysis. | Acetaminophen | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 2 | A time-course study further indicated that both wild-type and Cyp2e1-null mice had their serum acylcarnitine levels markedly elevated within the early hours of APAP treatment. | Acetaminophen | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 3 | The upregulation of PPARalpha activity following APAP treatment was transient in wild-type mice but was much more prolonged in Cyp2e1-null mice. | Acetaminophen | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 4 | Overall, serum metabolomics of APAP-induced hepatotoxicity revealed that the CYP2E1-mediated metabolic activation and oxidative stress following APAP treatment can cause irreversible inhibition of fatty acid oxidation, potentially through suppression of PPARalpha-regulated pathways. | Acetaminophen | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |
| 5 | Overall, serum metabolomics of APAP-induced hepatotoxicity revealed that the CYP2E1-mediated metabolic activation and oxidative stress following APAP treatment can cause irreversible inhibition of fatty acid oxidation, potentially through suppression of PPARalpha-regulated pathways. | Acetaminophen | cytochrome P450, family 2, subfamily e, polypeptide 1 | Mus musculus |