Title : Morphine increases brain levels of ferritin heavy chain leading to inhibition of CXCR4-mediated survival signaling in neurons.

Pub. Date : 2009 Feb 25

PMID : 19244528






3 Functional Relationships(s)
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1 This study focuses on the effect of mu-opioid receptor agonists on CXCR4 signaling in neurons and the mechanisms involved in regulation of neuronal CXCR4 by opiates. Opiate Alkaloids C-X-C motif chemokine receptor 4 Rattus norvegicus
2 By this mechanism, opiates could reduce the neuroprotective functions of CXCR4 and exacerbate neuropathology in opiate abusers who are affected by neuroinflammatory/infectious disorders, including neuroAIDS. Opiate Alkaloids C-X-C motif chemokine receptor 4 Rattus norvegicus
3 By this mechanism, opiates could reduce the neuroprotective functions of CXCR4 and exacerbate neuropathology in opiate abusers who are affected by neuroinflammatory/infectious disorders, including neuroAIDS. Opiate Alkaloids C-X-C motif chemokine receptor 4 Rattus norvegicus