Title : Disruption of the IS6-AID linker affects voltage-gated calcium channel inactivation and facilitation.

Pub. Date : 2009 Mar

PMID : 19237593






1 Functional Relationships(s)
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1 Here, we demonstrate that the IS6-alpha-interaction domain (AID) linker provides a rigid connection between the pore and Ca(V)beta/I-II loop complex by showing that IS6-AID linker polyglycine mutations accelerate Ca(V)1.2 (L-type) and Ca(V)2.1 (P/Q-type) VDI. polyglycine calcium voltage-gated channel subunit alpha1 A Homo sapiens