Title : Altered responses to propofol, but not ketamine, in mice deficient in the 65-kilodalton isoform of glutamate decarboxylase.

Pub. Date : 2009 May

PMID : 19233937






6 Functional Relationships(s)
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1 GABA is synthesized by two isoforms of glutamate decarboxylase (GAD), GAD65, and GAD67. gamma-Aminobutyric Acid glutamic acid decarboxylase 2 Mus musculus
2 However, the relative contributions of GAD65-mediated GABA synthesis to the in vivo actions of anesthetics remain unknown. gamma-Aminobutyric Acid glutamic acid decarboxylase 2 Mus musculus
3 To address this issue, we used mice deficient in the 65-kDa isoform of GAD and tested the hypothesis that partial reduction of GABA content in GAD65-deficient mice [GAD65(-/-)] would contribute to hypnotic and immobilizing actions of the anesthetics. gamma-Aminobutyric Acid glutamic acid decarboxylase 2 Mus musculus
4 To address this issue, we used mice deficient in the 65-kDa isoform of GAD and tested the hypothesis that partial reduction of GABA content in GAD65-deficient mice [GAD65(-/-)] would contribute to hypnotic and immobilizing actions of the anesthetics. gamma-Aminobutyric Acid glutamic acid decarboxylase 2 Mus musculus
5 In conclusion, GAD65(-/-) mice show a diminished response to propofol, but not ketamine, indicating that GAD65-mediated GABA synthesis plays an important role in hypnotic and immobilizing actions of propofol. gamma-Aminobutyric Acid glutamic acid decarboxylase 2 Mus musculus
6 In conclusion, GAD65(-/-) mice show a diminished response to propofol, but not ketamine, indicating that GAD65-mediated GABA synthesis plays an important role in hypnotic and immobilizing actions of propofol. gamma-Aminobutyric Acid glutamic acid decarboxylase 2 Mus musculus