Title : Oxidative DNA adducts after Cu(2+)-mediated activation of dihydroxy PCBs: role of reactive oxygen species.

Pub. Date : 2009 May 15

PMID : 19233261






3 Functional Relationships(s)
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1 Intervention studies with known reactive oxygen species (ROS) modifiers suggested that H(2)O(2), singlet oxygen, hydroxyl radical, and superoxide may also be involved in this PCB-mediated oxidative DNA damage. Reactive Oxygen Species pyruvate carboxylase Homo sapiens
2 Intervention studies with known reactive oxygen species (ROS) modifiers suggested that H(2)O(2), singlet oxygen, hydroxyl radical, and superoxide may also be involved in this PCB-mediated oxidative DNA damage. Reactive Oxygen Species pyruvate carboxylase Homo sapiens
3 These data indicate a mechanistic role for several ROS, in addition to copper, in PCB-induced DNA damage and provide further support for oxidative DNA damage in PCB-mediated carcinogenesis. Reactive Oxygen Species pyruvate carboxylase Homo sapiens