Title : Metoprolol represses PGC1alpha-mediated carnitine palmitoyltransferase-1B expression in the diabetic heart.

Pub. Date : 2009 Apr 1

PMID : 19233164






3 Functional Relationships(s)
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1 We therefore hypothesized that metoprolol represses CPT-1B by increasing USF-2-mediated repression of PGC1alpha. Metoprolol carnitine palmitoyltransferase 1B Rattus norvegicus
2 Chronic metoprolol treatment decreased the expression of CPT-1B in diabetic hearts. Metoprolol carnitine palmitoyltransferase 1B Rattus norvegicus
3 Metoprolol prevented the increase in PGC1alpha occupation of the CPT-1B promoter region observed in the diabetic heart without affecting PPAR-alpha occupation. Metoprolol carnitine palmitoyltransferase 1B Rattus norvegicus