Pub. Date : 2009 Apr 15
PMID : 19232538
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of THP-1 monocyte differentiation by phorbol 12-myristate 13-acetate (PMA) markedly increased SVCT2 mRNA, protein, and function. | Tetradecanoylphorbol Acetate | solute carrier family 23 member 2 | Homo sapiens |
| 2 | Induction of THP-1 monocyte differentiation by phorbol 12-myristate 13-acetate (PMA) markedly increased SVCT2 mRNA, protein, and function. | Tetradecanoylphorbol Acetate | solute carrier family 23 member 2 | Homo sapiens |
| 3 | When ascorbate was present during PMA-induced differentiation, the increase in SVCT2 protein expression was inhibited, but differentiation was enhanced. | Tetradecanoylphorbol Acetate | solute carrier family 23 member 2 | Homo sapiens |
| 4 | PMA-induced SVCT2 protein expression was blocked by inhibitors of protein kinase C (PKC), with most of the affect due to the PKCbetaI and betaII isoforms. | Tetradecanoylphorbol Acetate | solute carrier family 23 member 2 | Homo sapiens |
| 5 | In conclusion, PMA-induced monocyte-macrophage differentiation is enhanced by ascorbate and associated with increased expression and function of the SVCT2 protein through a pathway involving sustained activation of PKCbetaI/II, MAP kinase, NADPH oxidase, and NF-kappaB. | Tetradecanoylphorbol Acetate | solute carrier family 23 member 2 | Homo sapiens |