Title : Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers.

Pub. Date : 2009 Oct

PMID : 19221750






1 Functional Relationships(s)
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1 RESULTS: Apparent K ( i ) values for DHFR inhibition were 45, 26, and >200 nM for pralatrexate, methotrexate, and pemetrexed, respectively. Pemetrexed dihydrofolate reductase Homo sapiens