Pub. Date : 2009 Mar
PMID : 19221439
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To study their biological roles in vivo, we investigated CFTR-dependent duodenal HCO3- secretion in mouse models of Nherf1, Nherf2, and Pdzk1 loss of function. | Bicarbonates | cystic fibrosis transmembrane conductance regulator | Mus musculus |
| 2 | These data suggest that the NHERF proteins differentially modulate duodenal HCO3- secretion: while NHERF1 is an obligatory linker for beta2-AR stimulation of CFTR, NHERF2 confers inhibitory signals by coupling the LPA receptor to CFTR. | Bicarbonates | cystic fibrosis transmembrane conductance regulator | Mus musculus |
| 3 | These data suggest that the NHERF proteins differentially modulate duodenal HCO3- secretion: while NHERF1 is an obligatory linker for beta2-AR stimulation of CFTR, NHERF2 confers inhibitory signals by coupling the LPA receptor to CFTR. | Bicarbonates | cystic fibrosis transmembrane conductance regulator | Mus musculus |