Title : Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma.

Pub. Date : 2009 Aug

PMID : 19220580






4 Functional Relationships(s)
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1 Sorafenib-induced phosphorylation of c-met, p70S6K and 4EBP1 was significantly reduced when 10-0505 cells were co-treated with anti-human anti-HGF antibody, suggesting that treatment with sorafenib leads to increased HGF secretion and activation of c-met and mTOR targets. Sorafenib MET proto-oncogene, receptor tyrosine kinase Homo sapiens
2 Sorafenib-induced phosphorylation of c-met, p70S6K and 4EBP1 was significantly reduced when 10-0505 cells were co-treated with anti-human anti-HGF antibody, suggesting that treatment with sorafenib leads to increased HGF secretion and activation of c-met and mTOR targets. Sorafenib MET proto-oncogene, receptor tyrosine kinase Homo sapiens
3 Sorafenib-induced phosphorylation of c-met, p70S6K and 4EBP1 was significantly reduced when 10-0505 cells were co-treated with anti-human anti-HGF antibody, suggesting that treatment with sorafenib leads to increased HGF secretion and activation of c-met and mTOR targets. Sorafenib MET proto-oncogene, receptor tyrosine kinase Homo sapiens
4 Sorafenib-induced phosphorylation of c-met, p70S6K and 4EBP1 was significantly reduced when 10-0505 cells were co-treated with anti-human anti-HGF antibody, suggesting that treatment with sorafenib leads to increased HGF secretion and activation of c-met and mTOR targets. Sorafenib MET proto-oncogene, receptor tyrosine kinase Homo sapiens