Pub. Date : 2009 Feb
PMID : 19216858
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The research was designed to explore the inhibitory effects of Sal B on MMP-1, MMP-2 and MMP-9 activities. | salvianolic acid B | matrix metallopeptidase 2 | Homo sapiens |
| 2 | METHODS: Pure human interstitial collagenase (MMP-1) or gelatinase A (MMP-2) was activated by p-aminophenylmercuric acetate (APMA), and was incubated with Sal B for 1 h. The activities were observed by quenched fluorescent substrate. | salvianolic acid B | matrix metallopeptidase 2 | Homo sapiens |
| 3 | RESULTS: Sal B dose-dependently inhibited the human MMP-1 and MMP-2 activities in the range of 0.002 4 to 0.3 g/L, with 50% inhibiting concentration (IC(50)) of (0.090<0.015) g/L and (0.080<0.005) g/L respectively. | salvianolic acid B | matrix metallopeptidase 2 | Homo sapiens |