Title : In vitro complementation of Tdp1 deficiency indicates a stabilized enzyme-DNA adduct from tyrosyl but not glycolate lesions as a consequence of the SCAN1 mutation.

Pub. Date : 2009 May 1

PMID : 19211312






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 While Tdp1(-/-) mice appear phenotypically normal, extracts from Tdp1(-/-) fibroblasts exhibited deficiencies in processing 3"-phosphotyrosyl single-strand breaks and 3"-phosphoglycolate double-strand breaks (DSBs), but not 3"-phosphoglycolate single-strand breaks. dsbs tyrosyl-DNA phosphodiesterase 1 Mus musculus