Title : Influence of the G2677T/C3435T haplotype of MDR1 on P-glycoprotein trafficking and ibutilide-induced block of HERG.

Pub. Date : 2009 Jun

PMID : 19204737






1 Functional Relationships(s)
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Protein Name
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1 Coculture with fexofenadine(1 microM), an MDR1 substrate known to rescue misfolding in other membrane proteins, restored cell surface expression of MDR1 G2677T/C3435T and restored resistance to block HERG by ibutilide 200 nM (98.5+/-0.98% vs 42.3+/-2.2%, P<0.001). fexofenadine potassium voltage-gated channel subfamily H member 2 Homo sapiens