Pub. Date : 2009 Mar 3
PMID : 19202066
3 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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1 | Recently, we have shown that p53 regulates glucose metabolism through the IKK-NF-kappaB pathway and that, in the absence of p53, the positive feedback loop between IKK-NF-kappaB and glycolysis has an integral role in oncogene-induced cell transformation. | Glucose | tumor protein p53 | Homo sapiens | ||
2 | In p53-deficient cells, the O-GlcNAcylated IKKbeta and the activating phosphorylation of IKK were decreased by p65/NF-kappaB knockdown or glucose depletion. | Glucose | tumor protein p53 | Homo sapiens | ||
3 | Taken together, we propose a novel mechanism for the enhancement of NF-kappaB activity by loss of p53, which evokes positive feedback regulation from enhanced glucose metabolism to IKK in oncogenesis. | Glucose | tumor protein p53 | Homo sapiens |