Title : Novel semisynthetic triterpenoid AMR-Me inhibits telomerase activity in human leukemic CEM cells and exhibits in vivo antitumor activity against Dalton's lymphoma ascites tumor.

Pub. Date : 2009 Jun 18

PMID : 19201082






2 Functional Relationships(s)
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1 AMR-Me treatment resulted in suppression of hTERT expression and a concomitant inhibition of telomerase activity. methyl 25-hydroxy-3-oxoolean-12-en-28-oate telomerase reverse transcriptase Homo sapiens
2 Our results suggest that AMR-Me inhibits telomerase activity by decreasing the hTERT expression and induces apoptosis in human lymphoblastic leukemic CEM cells, thus providing the molecular basis for the development of AMR-Me as a novel chemotherapeutic agent against leukemia. methyl 25-hydroxy-3-oxoolean-12-en-28-oate telomerase reverse transcriptase Homo sapiens