Title : Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice.

Pub. Date : 2009 May

PMID : 19196849






2 Functional Relationships(s)
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1 CAR activators phenobarbital (PB) and 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) or corn oil (CO) were administered to C57BL/6 wild-type (WT) and CAR knockout (CAR-null) mice before and during induction of intrahepatic cholestasis using the secondary bile acid, lithocholic acid (LCA). 1,4-bis(2-(3,5-dichloropyridyloxy))benzene nuclear receptor subfamily 1, group I, member 3 Mus musculus
2 CAR activators phenobarbital (PB) and 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) or corn oil (CO) were administered to C57BL/6 wild-type (WT) and CAR knockout (CAR-null) mice before and during induction of intrahepatic cholestasis using the secondary bile acid, lithocholic acid (LCA). 1,4-bis(2-(3,5-dichloropyridyloxy))benzene nuclear receptor subfamily 1, group I, member 3 Mus musculus