Title : Differential effects of cholesterol and phytosterols on cell proliferation, apoptosis and expression of a prostate specific gene in prostate cancer cell lines.

Pub. Date : 2009

PMID : 19186008






3 Functional Relationships(s)
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1 BACKGROUND: The purpose of our study was to show the apoptotic and anti-proliferative effects of phytosterols as distinct from cholesterol effects on prostate cancer cell lines, and also their differential expression of caveolin-1, and a prostate specific gene, PCGEM1. Phytosterols PCGEM1 prostate-specific transcript Homo sapiens
2 CONCLUSIONS: Phytosterol inhibition of PCGEM1 and cell growth and the overexpression of caveolin-1, suggests that poor disease prognosis anchors on the ability of caveolin-1 to regulate downstream oncogene(s) and apoptosis genes. Phytosterols PCGEM1 prostate-specific transcript Homo sapiens
3 Sterol regulation of PCGEM1 expression suggests its potential as biomarker for prediction of neoplasms that would be responsive to chemoprevention by phytosterols. Phytosterols PCGEM1 prostate-specific transcript Homo sapiens