Title : Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-amino-4-deoxy-5,8,10-trideazapteroyl-d,l-4'-methyleneglutamic acid (CH-1504) and its analogs.

Pub. Date : 2009 Apr 1

PMID : 19174154






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 This class is characterized by retention of dihydrofolate reductase (DHFR; EC 1.5.1.3) as their locus of action and transport by the reduced folate carrier (RFC; SLC19A1), but their lack of metabolism by known pathways of antifolate (e.g., methotrexate (MTX)) metabolism. Folic Acid solute carrier family 19 member 1 Homo sapiens