Title : Differential induction of cytochrome P450 1A1 and 1B1 mRNA in primary cultured bovine hepatocytes treated with TCDD, PBDD/Fs and feed ingredients.

Pub. Date : 2009 Mar 28

PMID : 19167471






4 Functional Relationships(s)
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1 Differential induction of cytochrome P450 1A1 and 1B1 mRNA in primary cultured bovine hepatocytes treated with TCDD, PBDD/Fs and feed ingredients. Polychlorinated Dibenzodioxins cytochrome P450 1B1 Bos taurus
2 This study investigates the dose-dependent expression of CYP1A1 and CYP1B1 in primary cultured bovine hepatocytes exposed to TCDD, several polybrominated dibenzo-p-dioxins and furans (PBDD/Fs) congeners and fish oil used as animal feed ingredients to identify their dioxin-like potentials. Polychlorinated Dibenzodioxins cytochrome P450 1B1 Bos taurus
3 Quantitative real time polymerase chain reaction analysis (qRT-PCR) showed that relative mRNA levels for CYP1A1 and CYP1B1 exhibited a dose-dependent induction by TCDD. Polychlorinated Dibenzodioxins cytochrome P450 1B1 Bos taurus
4 The EC(50) of the TCDD concentration for CYP1A1 expression was approximately 4-fold less than that of CYP1B1. Polychlorinated Dibenzodioxins cytochrome P450 1B1 Bos taurus