Title : Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity.

Pub. Date : 2009 Feb 1

PMID : 19155497






1 Functional Relationships(s)
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1 After preparing serially truncated PP2Ac alpha promoter luciferase constructs, we found that the region stretching around 240 bases upstream from the translation initiation site was of functional significance and included a cAMP response element motif flanked by three GC boxes. Cyclic AMP protein phosphatase 2 catalytic subunit alpha Homo sapiens