Pub. Date : 2009 Feb
PMID : 19151729
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner. | NAD | tumor necrosis factor | Homo sapiens |
| 2 | We show here that intracellular NAD concentration promotes TNF synthesis by activated immune cells. | NAD | tumor necrosis factor | Homo sapiens |
| 3 | Using a positive screen, we have identified Sirt6, a member of the sirtuin family, as the NAD-dependent enzyme able to regulate TNF production by acting at a post-transcriptional step. | NAD | tumor necrosis factor | Homo sapiens |