Title : Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer.

Pub. Date : 2009 Jan 15

PMID : 19147759






1 Functional Relationships(s)
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1 In vivo, docetaxel + DIM-C-pPhC(6)H(5) reduced lung weights by 57% compared with 39% by docetaxel or 22% by DIM-C-pPhC(6)H(5) alone, induced apoptosis in 43% of the tumor cells compared with 29% and 22% in tumors treated with docetaxel and DIM-C-pPhC(6)H(5), respectively, and increased procaspase-3 cleavage compared with either agent alone. Docetaxel caspase 3 Homo sapiens