Pub. Date : 2009 Mar
PMID : 19144695
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anaphylatoxin C5a contributes to the pathogenesis of cisplatin-induced nephrotoxicity. | Cisplatin | hemolytic complement | Mus musculus |
| 2 | In this study, we investigated the role of anaphylatoxin C5a in the pathogenesis of cisplatin-mediated nephrotoxicity. | Cisplatin | hemolytic complement | Mus musculus |
| 3 | However, pretreatment with C5 or C5a restores sensitivity to cisplatin-induced nephrotoxicity in C5-deficient mice. | Cisplatin | hemolytic complement | Mus musculus |
| 4 | In conclusion, our findings suggest that C5a plays an important role in the pathogenesis of cisplatin nephrotoxicity. | Cisplatin | hemolytic complement | Mus musculus |