Pub. Date : 2009 Apr
PMID : 19139152
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | One example of a clinically important compound class that potently inhibits hERG trafficking are cardiac glycosides. | Glycosides | ETS transcription factor ERG | Homo sapiens |
| 2 | We have shown previously that inhibition of hERG trafficking by cardiac glycosides is initiated via direct block of Na(+)/K(+) pumps and not via off-target interactions with hERG or any other protein. | Glycosides | ETS transcription factor ERG | Homo sapiens |
| 3 | Our data suggest a novel mechanism for drug-induced trafficking inhibition in which cardiac glycosides produce a [K(+)](i)-mediated conformational defect directly in the hERG channel protein. | Glycosides | ETS transcription factor ERG | Homo sapiens |