Title : Cooperative activation of the ATR checkpoint kinase by TopBP1 and damaged DNA.

Pub. Date : 2009 Apr

PMID : 19139065






2 Functional Relationships(s)
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1 We show that base adducts caused by a potent carcinogen, benzo[a]pyrene diol epoxide (BPDE), constitute a strong signal for TopBP1-dependent ATR kinase activity on Chk1 and p53. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide checkpoint kinase 1 Homo sapiens
2 We show that base adducts caused by a potent carcinogen, benzo[a]pyrene diol epoxide (BPDE), constitute a strong signal for TopBP1-dependent ATR kinase activity on Chk1 and p53. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide checkpoint kinase 1 Homo sapiens