Title : An analysis of enzyme kinetics data for mitochondrial DNA strand termination by nucleoside reverse transcription inhibitors.

Pub. Date : 2009 Jan

PMID : 19132079






1 Functional Relationships(s)
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1 The model predicts an approximately 1000-fold difference in the activated drug concentration required for a 50% probability of mtDNA strand termination between the activated di-deoxy analogs d4T, ddC, and ddI (activated to ddA) and the activated forms of the analogs 3TC, TDF, AZT, FTC, and ABC. bis(p-chlorophenyl)acetic acid ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens