Pub. Date : 2009 Apr 15
PMID : 19125692
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recombinant C4ST-1 showed a substrate preference for chondroitin and catalysed the 4-O-sulfation of GalNAc residues, a highly frequent modification of CS in the embryos of zebrafish as well as other vertebrates. | Chondroitin Sulfates | carbohydrate (chondroitin 4) sulfotransferase 11 | Danio rerio |
| 2 | Functional knockdown of C4ST-1 with specific antisense morpholino-oligonucleotides led to a marked decrease in the 4-O-sulfation and amount of CS in the embryos. | Chondroitin Sulfates | carbohydrate (chondroitin 4) sulfotransferase 11 | Danio rerio |
| 3 | These results suggest that 4-O-sulfated CS formed by C4ST-1 is essential for somitic muscle differentiation and motor axon guidance in zebrafish development. | Chondroitin Sulfates | carbohydrate (chondroitin 4) sulfotransferase 11 | Danio rerio |