Title : FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells.

Pub. Date : 2009 Feb 27

PMID : 19119142






1 Functional Relationships(s)
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1 In vitro kinetic studies revealed that FTY720 is a competitive inhibitor of ceramide synthase 2 toward dihydrosphingosine with an apparent K(i) of 2.15 microm. safingol ceramide synthase 2 Homo sapiens