Pub. Date : 2009 Feb
PMID : 19118083
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition. | Fingolimod Hydrochloride | cytochrome P450 family 4 subfamily F member 2 | Homo sapiens |
| 2 | The sphingosine-1-phosphate receptor modulator fingolimod is predominantly hydroxylated by cytochrome CYP4F2. | Fingolimod Hydrochloride | cytochrome P450 family 4 subfamily F member 2 | Homo sapiens |
| 3 | In vitro experiments showed that ketoconazole significantly inhibited the oxidative metabolism of fingolimod by human liver microsomes and by recombinant CYP4F2. | Fingolimod Hydrochloride | cytochrome P450 family 4 subfamily F member 2 | Homo sapiens |