Title : Effect of tamoxifen and retinoic acid on bradykinin induced proliferation in MCF-7 cells.

Pub. Date : 2009 Feb 15

PMID : 19115248






2 Functional Relationships(s)
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1 The combined action of tamoxifen/all-trans retinoic acid was advantageous in MCF-7 cells, reducing cell proliferation, Bcl-2 and c-Myc protein levels and increasing E-Cadherin protein levels and Gap junctional Intercellular Communication. Tamoxifen MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 The co-incubation of bradykinin-MCF-7 cells with tamoxifen/all-trans retinoic acid reduced cell proliferation, ERK1/2 activity, as well as Bcl-2, c-Myc, and bradykinin receptor-2 levels, without altering the enhanced E-cadherin levels induced by tamoxifen/all-trans retinoic acid. Tamoxifen MYC proto-oncogene, bHLH transcription factor Homo sapiens