Pub. Date : 2009 Jun
PMID : 19113817
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cellular stimulation by TNF-alpha induced NADPH-dependent superoxide production in the endosomal compartment, and this ROS was required for IKK-mediated activation of NF-kappaB. | Superoxides | tumor necrosis factor | Homo sapiens |
| 2 | Inhibiting endocytosis reduced the ability of TNF-alpha to induce both NADPH-dependent endosomal superoxide and NF-kappaB, supporting the notion that redox-dependent signaling of the receptor occurs in the endosome. | Superoxides | tumor necrosis factor | Homo sapiens |
| 3 | Studies using both Nox2 siRNA and Nox2-knockout primary fibroblasts indicated that Nox2 was critical for TNF-alpha-mediated induction of endosomal superoxide. | Superoxides | tumor necrosis factor | Homo sapiens |