Title : Endosomal Nox2 facilitates redox-dependent induction of NF-kappaB by TNF-alpha.

Pub. Date : 2009 Jun

PMID : 19113817






3 Functional Relationships(s)
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1 Cellular stimulation by TNF-alpha induced NADPH-dependent superoxide production in the endosomal compartment, and this ROS was required for IKK-mediated activation of NF-kappaB. Superoxides tumor necrosis factor Homo sapiens
2 Inhibiting endocytosis reduced the ability of TNF-alpha to induce both NADPH-dependent endosomal superoxide and NF-kappaB, supporting the notion that redox-dependent signaling of the receptor occurs in the endosome. Superoxides tumor necrosis factor Homo sapiens
3 Studies using both Nox2 siRNA and Nox2-knockout primary fibroblasts indicated that Nox2 was critical for TNF-alpha-mediated induction of endosomal superoxide. Superoxides tumor necrosis factor Homo sapiens