Title : Nelfinavir induces the unfolded protein response in ovarian cancer cells, resulting in ER vacuolization, cell cycle retardation and apoptosis.

Pub. Date : 2009 Feb

PMID : 19106637






2 Functional Relationships(s)
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1 Nelfinavir significantly changed the morphology of ovarian cancer cells, resulting in formation of large ER-derived vacuoles and induced upregulation of the hsp70 heat shock family member BiP (GRP78) which accumulated within swollen ER membranes. Nelfinavir heat shock protein family A (Hsp70) member 5 Homo sapiens
2 Nelfinavir significantly changed the morphology of ovarian cancer cells, resulting in formation of large ER-derived vacuoles and induced upregulation of the hsp70 heat shock family member BiP (GRP78) which accumulated within swollen ER membranes. Nelfinavir heat shock protein family A (Hsp70) member 5 Homo sapiens