Title : Noninvasive functional imaging of P-glycoprotein-mediated doxorubicin resistance in a mouse model of hereditary breast cancer to predict response, and assign P-gp inhibitor sensitivity.

Pub. Date : 2009 Mar

PMID : 19093112






1 Functional Relationships(s)
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1 CONCLUSIONS: Quantified (99m)Tc-MIBI efflux has potential to: (1) noninvasively assign Mdr1 expression levels, (2) predict the therapeutic impact of a P-gp inhibitor, and (3) noninvasively assess the probability of drug resistance. Technetium Tc 99m Sestamibi phosphoglycolate phosphatase Mus musculus