Pub. Date : 2009 Feb 20
PMID : 19091748
18 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 2 | Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 3 | Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 4 | Slc2a5 (Glut5) is essential for the absorption of fructose in the intestine and generation of fructose-induced hypertension. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 5 | Here we demonstrate that Glut5 (Slc2a5) deletion reduced fructose absorption by approximately 75% in the jejunum and decreased the concentration of serum fructose by approximately 90% relative to wild-type mice on increased dietary fructose. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 6 | Here we demonstrate that Glut5 (Slc2a5) deletion reduced fructose absorption by approximately 75% in the jejunum and decreased the concentration of serum fructose by approximately 90% relative to wild-type mice on increased dietary fructose. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 7 | Here we demonstrate that Glut5 (Slc2a5) deletion reduced fructose absorption by approximately 75% in the jejunum and decreased the concentration of serum fructose by approximately 90% relative to wild-type mice on increased dietary fructose. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 8 | Here we demonstrate that Glut5 (Slc2a5) deletion reduced fructose absorption by approximately 75% in the jejunum and decreased the concentration of serum fructose by approximately 90% relative to wild-type mice on increased dietary fructose. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 9 | Here we demonstrate that Glut5 (Slc2a5) deletion reduced fructose absorption by approximately 75% in the jejunum and decreased the concentration of serum fructose by approximately 90% relative to wild-type mice on increased dietary fructose. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 10 | Here we demonstrate that Glut5 (Slc2a5) deletion reduced fructose absorption by approximately 75% in the jejunum and decreased the concentration of serum fructose by approximately 90% relative to wild-type mice on increased dietary fructose. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 11 | However, whereas Glut5(+/+) mice showed enhanced salt absorption in their jejuna in response to luminal fructose and developed systemic hypertension when fed a high fructose (60% fructose) diet for 14 weeks, Glut5(-/-) mice did not display fructose-stimulated salt absorption in their jejuna, and they experienced a significant impairment of nutrient absorption in their intestine with accompanying hypotension as early as 3-5 days after the start of a high fructose diet. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 12 | However, whereas Glut5(+/+) mice showed enhanced salt absorption in their jejuna in response to luminal fructose and developed systemic hypertension when fed a high fructose (60% fructose) diet for 14 weeks, Glut5(-/-) mice did not display fructose-stimulated salt absorption in their jejuna, and they experienced a significant impairment of nutrient absorption in their intestine with accompanying hypotension as early as 3-5 days after the start of a high fructose diet. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 13 | However, whereas Glut5(+/+) mice showed enhanced salt absorption in their jejuna in response to luminal fructose and developed systemic hypertension when fed a high fructose (60% fructose) diet for 14 weeks, Glut5(-/-) mice did not display fructose-stimulated salt absorption in their jejuna, and they experienced a significant impairment of nutrient absorption in their intestine with accompanying hypotension as early as 3-5 days after the start of a high fructose diet. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 14 | However, whereas Glut5(+/+) mice showed enhanced salt absorption in their jejuna in response to luminal fructose and developed systemic hypertension when fed a high fructose (60% fructose) diet for 14 weeks, Glut5(-/-) mice did not display fructose-stimulated salt absorption in their jejuna, and they experienced a significant impairment of nutrient absorption in their intestine with accompanying hypotension as early as 3-5 days after the start of a high fructose diet. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 15 | Examination of the intestinal tract of Glut5(-/-) mice fed a high fructose diet revealed massive dilatation of the caecum and colon, consistent with severe malabsorption, along with a unique adaptive up-regulation of ion transporters. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 16 | We conclude that Glut5 is essential for the absorption of fructose in the intestine and plays a fundamental role in the generation of fructose-induced hypertension. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 17 | We conclude that Glut5 is essential for the absorption of fructose in the intestine and plays a fundamental role in the generation of fructose-induced hypertension. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |
| 18 | Deletion of Glut5 results in a serious nutrient-absorptive defect and volume depletion only when the animals are fed a high fructose diet and is associated with compensatory adaptive up-regulation of ion-absorbing transporters in the colon. | Fructose | solute carrier family 2 (facilitated glucose transporter), member 5 | Mus musculus |