Title : New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity.

Pub. Date : 2009 Jan 15

PMID : 19091581






2 Functional Relationships(s)
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1 The very high MAO-B selectivity for 4i can be also explained in terms of the distance between the FAD and the compound, which was greater in the complex of MAO-A-4i as compared to the corresponding MAO-B complex. Flavin-Adenine Dinucleotide monoamine oxidase B Homo sapiens
2 The very high MAO-B selectivity for 4i can be also explained in terms of the distance between the FAD and the compound, which was greater in the complex of MAO-A-4i as compared to the corresponding MAO-B complex. Flavin-Adenine Dinucleotide monoamine oxidase B Homo sapiens