Title : Synthesis, conformational analysis and immunological activity of beta3Phe-substituted Cyclolinopeptide A analogues.

Pub. Date : 2009 Mar

PMID : 19089804






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CLA, a natural, highly hydrophobic cyclic nonapeptide with sequence c(Pro(1)-Pro(2)-Phe(3)-Phe(4)-Leu(5)-Ile(6)-Ile(7)-Leu(8)-Val(9)-), isolated from linseed oil, was found to possess a strong immunosuppressive activity comparable, in low doses, with that of CsA, with a mechanism that depends on the inhibition of the interleukin-1 and interleukin-2 action. Linseed Oil clasper Mus musculus